Antibody interactions

news at hgmp.mrc.ac.uk news at hgmp.mrc.ac.uk
Thu Feb 17 09:44:37 EST 2000


Could the epitopes  be overlapping?
<daemon at hgmp.mrc.ac.uk [mailto:daemon at hgmp.mrc.ac.uk] On Behalf Of>
wrote in
message news:88gdui$ipg$1 at mercury.hgmp.mrc.ac.uk...
>
>
>
> -----Original Message-----
> From: Robert Burns [mailto:burns at sasa.gov.uk]
> Sent: 16 February 2000 11:36
> To: diagnost at net.bio.net
> Subject: Antibody interactions
>
>
> We have come across a curious phenomenon when making cocktails of
> monoclonals. Two of our mab/Alk.phos conjugates which detect Potato
> Virus A
> pick up an isolate of this virus individually in ELISA. However when a
> mixture of the two conjugates is used we cannot detect this isolate.
Any
> ideas of what is going on?
>
>
> Robert Burns
>
>
>
> Antibody Unit
> SASA
> Craigs Road
> Edinburgh
> EH12 8NJ
>
> burns at sasa.gov.uk
>
>
> ---






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