The decisive goal of clinical biomarker discovery should be intended for developing high quality and low-cost disease detection/monitoring assays with high diagnostic accuracy. Innovative approaches are warranted for the discovery of clinical biomarkers, with faster bench to clinics timeline, to provide high quality and efficient patient care. At the same time, if we continue with the strategic and technological approaches that are currently being adopted for biomarker discovery and validation, most likely, it may take several years to find clinically viable biomarker/s for complex diseases like cancer or neurodegenerative or autoimmune or other human diseases. Therefore, an ideal clinical biomarker discovery platform, which can lead to the development of reliable and robust clinical diagnostics assays, should adopt an integrated approach that consists of comprehensive understanding of patients phenotypic, genetic and socio-environmental characteristics as well as biological and functional relevance of all biomolecules. In order to achieve these goals, two models for the discovery, selection and validation of clinically viable biomarkers are proposed in this scientific blog. Read the full blog: http://www.sciclips.com/sciclips/blogArticle.do?id=1022&blog=How%20to%20Identify%20Clinically%20Successful%20Biomarkers?