Job Available

[Leslie C. Griffith]

        Job Description: Laboratory Technician

A fulltime position is available for a research technician in the Biology
Department at Brandeis University. Brandeis is located in Waltham
Massachusetts, just outside Boston. Brandeis is an EOE.

My lab studies the role of calcium/calmodulin-dependent protein kinase II
in behavioral and synaptic plasticity using a multidisciplinary approach
(measurement of adult behaviors, protein chemistry, molecular biology,
genetics and electrophysiology). Recent publications include:

        Griffith, L.C., Verselis, L.M., Aitken, K.M., Kyriacou, C.P.,
Danho, W. and Greenspan, R.J. (1993) "Inhibition of
calcium/calmodulin-dependent protein kinase in Drosophila  disrupts
behavioral plasticity", Neuron  10:501-509

        Griffith, L.C. and Greenspan, R.J. (1993) "The diversity of
calcium/calmodulin-dependent protein kinase II isoforms in Drosophila  is
generated by alternative splicing of a single gene", J. Neurochem.
61:1534-1537

        Griffith, L.C., Wang, J., Zhong, Y., Wu, C.-F. and Greenspan, R.J.
(1994) "Calcium/calmodulin-dependent protein kinase II and potassium
channel subunit Eag similarly affect plasticity in Drosophila " Proc. Natl.
Acad. Sci. 91:10044-10048

        Wang, J., Renger, J., Griffith, L.C., Greenspan, R.J. and Wu, C.-F.
(1994) "Concomitant Alterations of  Physiological and Developmental
Plasticity at CaM kinase II-inhibited Synapses in Drosophila" Neuron
13:1373-1384

        GuptaRoy, B. and Griffith, L.C. (1996) "Functional characterization
of alternatively spliced isoforms of Drosophila  Ca2+/calmodulin-dependent
protein kinase II" J. Neurochem.  66:1282-1288

        GuptaRoy, B., Beckingham, K. and Griffith, L.C. (1996) "Functional
diversity of alternatively spliced isoforms of Drosophila
Ca2+/calmodulin-dependent protein kinase II: A role for the variable domain
in activation" J. Biol. Chem.  (In Press)

Duties of the position will include: maintenance of Drosophila  stocks,
setting up crosses to produce progeny for behavioral assays, behavioral
assays (courtship conditioning), data analysis, production of transgenic
stocks (microinjection and genetics) and chromosomal mapping. The
successful applicant has experience with Drosophila  culture and behavior.

Interested individuals can send me a resume via US mail or e-mail.




Leslie C. Griffith, MD PhD
Dept. of Biology
Bassine MS008
Brandeis University
415 South St.
Waltham, MA  02254-9110
phone (617)736-3125
FAX  (617)736-3107
GRIFFITH at VOLEN.BRANDEIS.EDU