Leslie C. Griffith
griffith at VOLEN.BRANDEIS.EDU
Fri Aug 9 12:45:05 EST 1996
Job Description: Laboratory Technician
A fulltime position is available for a research technician in the Biology
Department at Brandeis University. Brandeis is located in Waltham
Massachusetts, just outside Boston. Brandeis is an EOE.
My lab studies the role of calcium/calmodulin-dependent protein kinase II
in behavioral and synaptic plasticity using a multidisciplinary approach
(measurement of adult behaviors, protein chemistry, molecular biology,
genetics and electrophysiology). Recent publications include:
Griffith, L.C., Verselis, L.M., Aitken, K.M., Kyriacou, C.P.,
Danho, W. and Greenspan, R.J. (1993) "Inhibition of
calcium/calmodulin-dependent protein kinase in Drosophila disrupts
behavioral plasticity", Neuron 10:501-509
Griffith, L.C. and Greenspan, R.J. (1993) "The diversity of
calcium/calmodulin-dependent protein kinase II isoforms in Drosophila is
generated by alternative splicing of a single gene", J. Neurochem.
Griffith, L.C., Wang, J., Zhong, Y., Wu, C.-F. and Greenspan, R.J.
(1994) "Calcium/calmodulin-dependent protein kinase II and potassium
channel subunit Eag similarly affect plasticity in Drosophila " Proc. Natl.
Acad. Sci. 91:10044-10048
Wang, J., Renger, J., Griffith, L.C., Greenspan, R.J. and Wu, C.-F.
(1994) "Concomitant Alterations of Physiological and Developmental
Plasticity at CaM kinase II-inhibited Synapses in Drosophila" Neuron
GuptaRoy, B. and Griffith, L.C. (1996) "Functional characterization
of alternatively spliced isoforms of Drosophila Ca2+/calmodulin-dependent
protein kinase II" J. Neurochem. 66:1282-1288
GuptaRoy, B., Beckingham, K. and Griffith, L.C. (1996) "Functional
diversity of alternatively spliced isoforms of Drosophila
Ca2+/calmodulin-dependent protein kinase II: A role for the variable domain
in activation" J. Biol. Chem. (In Press)
Duties of the position will include: maintenance of Drosophila stocks,
setting up crosses to produce progeny for behavioral assays, behavioral
assays (courtship conditioning), data analysis, production of transgenic
stocks (microinjection and genetics) and chromosomal mapping. The
successful applicant has experience with Drosophila culture and behavior.
Interested individuals can send me a resume via US mail or e-mail.
Leslie C. Griffith, MD PhD
Dept. of Biology
415 South St.
Waltham, MA 02254-9110
GRIFFITH at VOLEN.BRANDEIS.EDU
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