Tom tpietri at curie.fr
Thu Oct 30 09:22:38 EST 1997

In article (Dans l'article) <ssotillos-2410971049310001 at powmod.cbm.uam.es>,
ssotillos at trasto.cbm.uam.es (Sol Sotillos) wrote (écrivait) :

> Hello, does anybody know what is the meaning of kuzbanian (the name of a
> new neurogenic gene) and in which language?
> thank you very much

Kuzbanian is a ADAM protein (or MDC protein) : it is the ADAM-10.
ADAM protein are -A- -D-isintegrin -A-nd -M-ettaloprotease.

ADAM-10 degrade basic myelin and have 2 forms, nativ form and a form
without prodomain (this form is a activ metalloprotease).
In vitro, the knock-out of ADAM-10 conduct all of cells in neural way :
ADAM-10 active Notch protein wich permit fixation of Delta protein ->
lateral inhibition.

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