[Drosophila] Graduate Position: MichiganStateU. Evol. Genetics/Development.

Alexander Shingleton via dros%40net.bio.net (by shingle9 from msu.edu)
Mon Sep 14 10:17:08 EST 2009

PhD Studentships in Evolutionary Genetics and Integrative =20
Developmental Biology, Michigan State University, USA.

Four graduate positions in evolutionary genetics/developmental biology =20=

are available in the laboratories of Dr. Alex Shingleton and Dr. Ian =20
Dworkin in the Department of Zoology and Program in Ecology, =20
Evolutionary Biology and Behavior at Michigan State University. The =20
positions are funded as part of three NSF grants working at the =20
interface of evolution, development and genetics. The Shingleton and =20
Dworkin laboratories work closely together and employ molecular, =20
genetic, genomic, physiological and behavioral methods to address =20
their research questions, using Drosophila as a model organism. More =20
details on the research being conducted in the laboratories are =20
available at www.msu.ed/~shingle9 and www.msu.edu/~idworkin. Students =20=

will be immersed in an integrative and collaborative research =20
experience within the diverse and dynamic life-science community at =20
Michigan State University.

  Potential projects for graduate students include:

1) Elucidating the molecular and developmental regulation of =20
morphological scaling relationships. Previous research in the =20
Shingleton lab has identified the insulin-signaling pathway as being =20
differently regulated in organs that differ in their scaling =20
relationship with body size. The goal of the project is to elucidate =20
the molecular basis for this differential regulation.

2) Exploring the evolution of wing-body scaling in Drosophila =20
populations. This project involves applying artificial selection on =20
scaling relationships in Drosophila and elucidating the genetic and =20
developmental basis for the selection response.

3) Examining the role of conditional and pleiotropic genetic effects =20
in the evolutionary process, and mapping genetic modifiers that =20
contribute to these effects. Previous work (Dworkin et al. 2009) =20
demonstrated that a genetic modifier of the allelic effects of a =20
mutant results in profound difference in phenotypes. The student will =20=

fine map the genetic modifier and examine its potential pleiotropic =20
contributions in natural populations.

4) Explore the effects of different genetic backgrounds on gene =20
interactions and ordering of allelic series for mutations that affect =20=

wing development and shape. This work will examine the effects of a =20
series of mutations in different =93wild-type=94 genetic backgrounds, =20=

across several rearing environments (manipulations of diet and =20

The projects will suit students with an interest in evolutionary =20
genetics and/or integrative developmental biology. The ideal candidate =20=

should have good general laboratory skills, with a firm grasp of basic =20=

statistical methods.

Michigan State University is a large land-grant institution with an =20
outstanding faculty and inter-disciplinary programs at the =20
departmental and university levels.  Interested applicants are =20
encouraged to review additional background on faculty and graduate =20
programs in Zoology (http://www.zoology.msu.edu), and in the Ecology, =20=

Evolutionary Biology and Behavior (EEBB) program =

Applicants should submit a statement of interest, a CV, GRE scores and =20=

their cumulative GPA along with names and contact information of three =20=

references (everything as one PDF document) to shingle9 from msu.edu. =20
Applications will be accepted until the positions are filled. The =20
start date is September 2010, although applicants who wish to start =20
sooner should also apply.

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