[Drosophila] Postdoctoral Position in Drosophila Aging and Physiology

Thomas Flatt via dros%40net.bio.net (by flatt.thomas from gmail.com)
Fri Sep 25 07:32:52 EST 2009

Postdoctoral Position in Drosophila Aging and Physiology

A postdoctoral research position in the biology of Drosophila aging
and physiology is available in the group of Dr. Thomas Flatt at the
University of Veterinary Medicine (Department of Biomedical Research,
Institute of Population Genetics), Vienna, Austria (http://
i122server.vu-wien.ac.at/pop/Flatt_website/flatt_home.html). The
postdoc position is funded by a grant from the Austrian Science
Foundation (FWF) and will be for three years.

This research project will focus on the identification of the
molecular basis of the trade-off between reproduction and lifespan in
the fruit fly, Drosophila melanogaster, a powerful genetic model
system. In many organisms, from fruit flies to humans, reproduction
shortens lifespan, but the underlying mechanisms remain largely
unknown (see Flatt & Promislow 2007 in Science). Experiments in C.
elegans suggest that hormonal signals from the gonad affect longevity
(Hsin & Kenyon 1999 in Nature), and we have recently found that
germline ablation extends lifespan and affects insulin signaling in
Drosophila (Flatt et al. 2008 in PNAS). However, the details of this
systemic regulation of lifespan by the reproductive system remain
unclear. In our project we are interested in dissecting the endocrine
and physiological mechanisms that modulate the reproduction-longevity
trade-off. By employing mutant and transgene analysis, genetic
manipulation of the gonad, epistasis experiments, hormonal
manipulations, and physiological measurements we will examine the
mechanisms whereby signals from the reproductive system modulate

We are seeking a highly talented, dynamic, independent, and self-
motivated young biologist with good social skills. The successful
candidate will have a Ph.D. and a strong background in genetics and
molecular biology using the Drosophila system. Some background in the
biology of aging, evolutionary biology, and/or physiology and
endocrinology would be ideal, but is not required. The working
language in the laboratory is English, so the candidate should be
proficient in spoken and written English. German skills, although
helpful, are not essential. The initial appointment will be made for
one year, with a possible extension to up to three years. The annual
salary is 54,180 Euro (before tax). The position is available as of
now, but the starting date is negotiable.

In a 2009 world-wide survey by the William M. Mercer Institute, Vienna
ranked first world-wide in terms of standards of living. Vienna is a
beautiful, historical yet modern city, located in the heart of Europe,
close to the Alps and to major cities like Munich, Zurich, Prague, and
Budapest. Being famous for its concert sites, opera houses, theathers,
museums, and coffee shops, Vienna also provides great outdoor
activities, such as sailing on the Neusiedler See, ice skating, biking
and hiking in the Viennese woods and the nearby Alps. Moreover, the
city has a wide range of great restaurants, bars, wineries, cinemas,
clubs, libraries, galleries, and art collections. The Vienna area is
also an exceptional and highly international research environment.
Four major life science universities and three world-class research
institutes (GMI, IMBA, IMP) provide a dynamic and interactive setting.
Vienna hosts an active Drosophila community, and the onsite
availability of the Drosophila RNAi center (VDRC) provides a great
opportunity for functional Drosophila work. In population genetics and
evolutionary biology, the Vienna research area also provides excellent
prospects, due to a growing number of evolutionary research groups.

To apply for this position, please send a single pdf file including:
(1) a cover letter explaining why you would like to join our group,
(2) your Curriculum Vitae (including a description of your skills),
(3) your publication list, (4) a statement of research interests, and
(5) contact details for 2-3 academic references who are willing to
write a reference letter on your behalf to the following email
address: thomas.flatt from vu-wien.ac.at

Informal inquiries are welcome and should be sent to the same e-mail
address. For further information see (http://i122server.vu-wien.ac.at/

The deadline for submission is 31 October 2009.

Dr. Thomas Flatt
University of Veterinary Medicine
Department of Biomedical Research
Institute of Population Genetics
Veterinärplatz 1 / Josef Baumann Gasse 1
A-1210 WIEN

VOX +43(0)1-25077-4334
FAX +43(0)1-25077-4390
E-mail: Thomas.Flatt from vu-wien.ac.at

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