GFP mouse knock-in

A. S. Goustin Lab hivlab at CMB.BIOSCI.WAYNE.EDU
Sun Feb 1 23:49:30 EST 1998


Has anybody produced a mouse knock-in using GFP as a reporter?

In other words, has any group replaced the open reading frame of a gene
with the GFP open reading frame, so that a mouse would result in which GFP
expression would reflect the activation of that gene's regulatory
elements?  Would work when the knock-in is heterozygous, so that the loss
of that gene's ORF would probably not result in a significant phenotype.




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