A question of probability.

Toby Bradshaw toby at stein1.u.washington.edu
Thu Oct 14 16:36:49 EST 1993


In article <1993Oct14.144422.1 at kean.ucs.mun.ca>,
 <roger at kean.ucs.mun.ca> wrote:
>	When searching for linkage to a previously unknown locus, a LOD of 
>3.0 approximates to a 95% probability of linkage (not the 1000 to 1 
>odds frequently cited).

That depends on the map length and marker density, hence the number
of "independent" tests.

>How is this changed if we are looking for linkage to 
>a single candidate locus as in the present example?

In a single test, the LOD score and p value are the same, if my
intuition is correct.  Ellen Wijsman -- are you listening?

Toby Bradshaw                       |
Department of Biochemistry          |  Will make genetic linkage maps
and College of Forest Resources     |            for food.
University of Washington, Seattle   |
toby at u.washington.edu               |



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