Large Allele numbers in LINKAGE ( >14 )

sheldonp at CPU1.OMRF.UOKHSC.EDU sheldonp at CPU1.OMRF.UOKHSC.EDU
Thu Jul 7 16:08:24 EST 1994


In my group we are scanning the human genome for genes responsible for a 
complex disease.  Not too far into the search, we have run into a few 
markers which have 16 or more alleles.  I have been able to modify the 
LINKAGE programs (v 5.2) to allow up to 14 alleles, but past that, I get 
compiling errors informing me that I am out of memory.  Further examination
tells me that the UNKNOWN program creates a matrix of the size:
  (maxall)*(maxall+1)/2  X (maxall)*(maxall+1)/2
which is too big for DOS to handle.  

My question is, is there any way to get around this limitation by splitting
up the pedigree set, or some other method?

Thank-you in advance

Peter Sheldon

Peter-Sheldon at omrf.uokhsc.edu



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