comparing allele frequencies

BOWDEN at MGRP.BGSM.WFU.EDU BOWDEN at MGRP.BGSM.WFU.EDU
Fri Mar 11 10:17:35 EST 1994


	This is probably a dumb question, but... we have genotyped a micro-
satellite in a large number of caucasian and african-american samples and 
would like to compare the allele frequency distribution to see if they are
different. I did this using a contingency table to calculate chi square 
and there is a significant difference. I seem to recall thought that if any
of the cells has less than 5 elements in it, chi square is not the appropriate
way to go. What is the right way to do this, and more importantly, is there
some textbook or other source which would show a simple-minded molecular bio-
logist how to do it?

Don Bowden
Bowman Gray School of Medicine
bowden at mgrp.bgsm.wfu.edu



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