Inquires about linkage analysis

GDB User Support ussadm at gdb.org
Tue Apr 25 12:10:56 EST 1995


Hello People of bionet.molbio.gene-linkage,

We received a message in our E-Mail that would better be answered most likely by 
someone in this group (atleast I hope).  Please respond to her since I do not
know if she reads the newsgroups.  

Thank you,
Cathryn writes:
----------------Included message-------------------
Dear Sir or Madam,
	I wonder if you could give me some advice on linkage analysis - in the dog rather 
than the human 'though.  I am about to take up a position in Dr. Elaine 
Ostrander's laboratory at the Fred Hutchinson Cancer Research Institute in 
Seattle where my job will involve determining the order and spacing of canine 
microsatellite markers which have been putatively assigned to the same chromosomes 
using canine/rodent hybrid cell lines (there are < 10 markers in each group).  
Although I am familiar with the concepts of linkage analysis I am a newcomer to 
the practical details of actually performing linkage analysis experiments and as 
there is no one in my new lab particularly experienced in this field either I am 
trying to gather information before I get there.
	I will have access to 70 individuals from four families with which to do the 
linkage analysis and as far as I know there are just two generations available.  I 
wonder if you could me any advice as to the most suitable / appropriate programmes 
to use for this type of analysis, given the families I have available?  Another 
(trivial) consideration for me is that to date virtually all my computing 
experience is on the Macintosh so if I could use a programme which I could run on 
the Mac I'd be very happy, altho' I know this should only be a minor 
consideration! 
	I will be extremely appreciative of any help or advice you have the time to give 
me and I look forward to hearing from you.

Yours faithfully,


Cathryn Mellersh (PhD)

----------------End included message--------------
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