A decent program for Linkage Analysis

Gregory M. Acland gma2 at CORNELL.EDU
Sun Apr 30 08:03:11 EST 1995

By now, J. J. Campanella (jjc4 at po.CWRU.Edu) has been appropriately
castigated for his assaults on the various linkage programs, and the rigor
with they have been written and maintained, especially as they are all
public domain.

However, the point does remain that the programs are not user friendly for
naive or casual users, and the demand/need for access to such programs by
such users is going to increase.

What is the hope of someone setting up a client server system for linkage
analysis on the Net?. That way a user could have a Mac (or other warm and
fuzzy) client interface locally for converting pedigrees into a format
suitable for submission to a remote server running (eg:) the Linkage
package.  The pedigree analysis at the client end could be restricted to
input error, loop detection etc. The pedigree could then be  transferred to
a server running the likage analysis on a faster but less "user-friendly"
machine. This client server system would have, for instance, some of the
features of the Nentrez interface to Genbank, the Grateful Med interface to
Medline, the GDB/Accessor interface to GDB, and the BLAST system.  All of
these interfaces have adequately made much less "friendly" programs
available to a far wider audience than the respective cognoscenti.

Actually, a warm and fuzzzy Mac program that generated straight text files
for transfer (via wire or even sneaker-net) to a (horrors) DOS machine
would be adequate. I mean you can, and people do, enter pedigree data into
Excel on a Mac, cut and paste into Word, save as Text, translate into
PC-files and stick into a DOS-box. A more seamless way of doing this might
be adequate.

Gregory M. Acland        	       	       	       	       	  (607) 256-5684
Center for Canine Genetics & Reproduction       	  (607) 256-5689 [fax]
James A. Baker Institute for Animal Health      	   gma2 at cornell.edu
College of Veterinary Medicine
Cornell University
Hungerford Hill Rd, Ithaca, New York 14853

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