LOD score too high - answers
Daniel E. Weeks
dweeks at WATSON.HGEN.PITT.EDU
Fri Feb 10 09:59:52 EST 1995
On 9 Feb 1995, Daniel E. Weeks wrote:
> > To test the hypothesis of all linked against none
> > linked you'd have 1 - 0.0 - 2 - 0.0 - 3 against 1 - 0.5 - 2 - 0.5 - 3, which
> > would mean changing two intervals simultaneously.
> Unfortunately, this is exactly what LINKMAP does when it computes
> Ott's generalized lod score (which is described in his book).
Opps, it is ILINK which computes Ott's generalized lod score, not MLINK or
LINKMAP. David Curtis' discussion of MLINK was correct - MLINK does only
change one theta at a time, and, as pointed out, this may result in a 'lod
score' that is not a proper multipoint lod score because it was standardized
by the wrong likelihood.
-- Dan Weeks --
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