Course in analysis of multifactorial diseases

Geordie +1865 740 011 ayoung at vax.oxford.ac.uk
Wed Feb 15 09:22:52 EST 1995


                  WELLCOME SUMMER SCHOOLS

      FOURTEENTH ADVANCED COURSE 16th - 21st July 1995

The Wellcome Trust Centre for Human Genetics, University of Oxford 
Windmill Road, Headington, Oxford, OX3 7BN

       All email inquiries to: wss at umds.ac.uk.

HUMAN GENOME ANALYSIS: GENETIC ANALYSIS OF MULTIFACTORIAL DISEASES

An intensive computer-based course aimed at scientists actively involved 
in genetic analysis of multifactorial traits.  The following topics will be 
covered:

Programme

1.	Gel analysis

Operation of GENESCAN software for defining tracks and checking size 
standards on the ABI fluorescent 373A DNA sequencer.  Including sample sheet 
set up, installation of matrix files, analysis and pre-process parameters.

2.	Genotyping

Scoring of microsatellite results using GENOTYPER and GAS software, 
including setting up of macros files, export of data, allele binning and 
format conversions.

3.	Linkage

Introduction to basic concepts of linkage analysis, in particular, those 
related to non-Mendelian diseases.

4.	Sibpair Analysis

Comparison of identity-by-descent, identity-by-state and maximum 
likelihood methods of affected sib-pair analysis.  Analysis of quantitative 
traits.

5.	Lodscore analysis

Use of LINKAGE program to calculate likelihoods for general pedigrees, 
including construction of locus linkage maps, error checking and analysis of 
marker locus linked to disease.

6.	Affected Relative Methods

General non-parametric tests aimed at detecting linkage by examining 
correlation between the affected members of a pedigree.

7.	Associated Tests

Use of tests for linkage disequilibrium between markers and disease, 
construction and analysis of haplotypes.

Teaching will take the form of lectures by invited speakers, informal 
tutorials, hands-on computer sessions and analysis of disease family data 
sets.  There will also be an opportunity to analyse and discuss 
participants' own data sets.

Course Instructors

SUMIT BHATTICHARYYA, HEATHER CORDELL, JUNE DAVIES, SIW DANIELS, TONY 
MERRIMAN, LYNN PRITCHARD, PETER REED, JOHN TODD, JOE TERWILLIGER, MARGARET 
TOWN, DAN WEEKS,  ALAN YOUNG.

Confirmed speakers include:

MIKE BOEHNKE (Ann Arbor), ARAVINDA CHAKRAVARTI (Case Western), DOUG EASTON 
(Sutton), MARTIN FARRALL (Oxford), MARK LATHROP (Oxford),  MARGARET 
PERICAK-VANCE (Duke).

Participants

Applicants should be scientists at an advanced level of research 
(post-doctoral or equivalent).  Documentation verifying that the applicant 
is actively engaged in a linkage or family-based association study 
(animal/human) must be provided with the application, as well as evidence of 
access to a fluorescence-based automated genotyping system.  The course is 
subsidised by the Wellcome Trust for scientists based in academic 
institutions anywhere in the world.  This is a residential course, without 
exception, and there is a charge of 350 pounds Sterling towards board and
lodging.

Applications

There are no formal application forms, but applicants should send a hard 
copy of their full CV together with a 300 word outline of their research 
plans and supporting documentation, to Dr Pelin Faik, Course Co-ordinator, 
Division of Biochemistry & Molecular Biology, UMDS, Guy's Campus, London 
Bridge SE1 9RT.

Tel:  0171 403 6998
Fax:  0171 407 5281
Email: wss at umds.ac.uk.

	Closing date for applications is 14th April 1995
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    /   \   /                 |    /      Alan Young @ uk.ac.ox.vax
   /____/  /  ___    __       |___/
  /    /  /  /   |  /  |         /           "The bigger they are,
 /     \_/\__\__/|_/  /_________/               the harder they fall on you."



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