unusual inheritance of disease susceptibility

Grant Morahan morahan at wehi.edu.au
Sat Jun 17 00:01:58 EST 1995


Hello,

We have been analysing genetic susceptibility to an experimentally-induced
disease in mice.  The results are surprising. 
Inbred strain A -100% susceptible;
inbred strain B -100% resistant. 
(AxB)F1  - 50% are susceptible.  
F2 -  25% are susceptible. So far, so good.

But 50% of the ((AxB)xA)BC1 mice develop disease.
(We don't have results for the reciprocal BC yet). 

The problem is that the BC doesn't seem more susceptible than the F1.
Can anyone suggest a genetic model to explain these results? We haven't
been able to come up with one.
Any suggestions would be welcome.
-Grant

-- 
Grant Morahan, Ph.D.
The Walter and Eliza Hall Institute of Medical Research
Parkville, Victoria
AUSTRALIA



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