Complex diseases mapped by linkage?

David Curtis dcurtis at
Thu May 25 08:06:07 EST 1995

Looking for good examples of complex diseases where the pathogenic 
mutation has actually been identified and the initial localisation was (at 
least partly) through the use of a linkage strategy. Breast cancer is a good 
example, senile onset Alzheimer's disease is probably pushing it a bit. 
Other suggestions?


Dave Curtis (dcurtis at

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