Complex diseases mapped by linkage?
Dr David E Barton
dbarton at acer.gen.tcd.ie
Thu May 25 11:23:07 EST 1995
In article <dcurtis.169.000E1A8A at hgmp.mrc.ac.uk>,
David Curtis <dcurtis at hgmp.mrc.ac.uk> wrote:
>Looking for good examples of complex diseases where the pathogenic
>mutation has actually been identified and the initial localisation was (at
>least partly) through the use of a linkage strategy. Breast cancer is a good
>example, senile onset Alzheimer's disease is probably pushing it a bit.
What about non-polyposis colon cancer? The cloning was by homology to DNA
repair genes, but one HNPCC gene had been mapped to chromosome 2 first, and
when the repair gene also mapped there, they put 2 and 2 together!
| David Barton
| National Centre for Medical Genetics
| Our Lady's Hospital for Sick Children
| Crumlin, Dublin 12, Ireland.
| Tel 455 0515 Fax 455 8873
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