Complex diseases mapped by linkage?

Dr David E Barton dbarton at acer.gen.tcd.ie
Thu May 25 11:23:07 EST 1995


In article <dcurtis.169.000E1A8A at hgmp.mrc.ac.uk>,
David Curtis <dcurtis at hgmp.mrc.ac.uk> wrote:
>Looking for good examples of complex diseases where the pathogenic 
>mutation has actually been identified and the initial localisation was (at 
>least partly) through the use of a linkage strategy. Breast cancer is a good 
>example, senile onset Alzheimer's disease is probably pushing it a bit. 
>Other suggestions?
 
 What about non-polyposis colon cancer? The cloning was by homology to DNA
 repair genes, but one HNPCC gene had been mapped to chromosome 2 first, and
 when the repair gene also mapped there, they put 2 and 2 together!

 Cheers,  David.

  | David Barton
  | National Centre for Medical Genetics
  | Our Lady's Hospital for Sick Children
  | Crumlin, Dublin 12, Ireland.
  | Tel 455 0515 Fax 455 8873





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