COmplex diseases by linkage

Mike Miller mbmiller at SIRRONALD.WUSTL.EDU
Sat May 27 18:15:17 EST 1995

On 27 May 1995, Graham Dellaire wrote:

> Other complex diseases mapped by linkage 
> Cystic fibrosis (physical cloning)
> Amyotrophic lateral Sclerosis (ALS) (functional and position cloning)
> Waardenburg syndrome

I wonder what is meant by "complex" here.  I thought that cystic fibrosis 
and Waardenburg syndrome were "simple" (recessive and dominant, 
respectively) Mendelian disorders.  What makes them complex?  Is there 
heterogeneity or what?



Michael B. Miller, M.S., Ph.D.
Department of Psychiatry (Box 8134)
Washington University School of Medicine
4940 Children's Place,  St. Louis, MO 63110
office phone: (314) 362-9428    FAX: (314) 362-9420
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