Complex diseases mapped by linkage?

ROGER GREEN,MEDICINE,ST.JOHN'S,NF,CAN roger at kean.ucs.mun.ca
Mon May 29 07:17:50 EST 1995


In article <dcurtis.169.000E1A8A at hgmp.mrc.ac.uk>, dcurtis at hgmp.mrc.ac.uk (David Curtis) writes:
> Looking for good examples of complex diseases where the pathogenic 
> mutation has actually been identified and the initial localisation was (at 
> least partly) through the use of a linkage strategy. Breast cancer is a good 
> example, senile onset Alzheimer's disease is probably pushing it a bit. 
> Other suggestions?
> Dave Curtis (dcurtis at hgmp.mrc.ac.uk)

	What do you mean by complex?  In genetic terms, this is often taken 
to mean that several ( at least 2) genes are involved,  possibly with a 
requirement for environmental factors.
	The inherited cases of breast cancer involving BRCA1 and BRCA2 are 
SIMPLE Mendelian dominant traits involving mutation in only one gene.

Roger C. Green,	Faculty of Medicine               Phone: (709)737-6884
Memorial University , St. John's, Newfoundland    FAX  : (709)737-7010



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