Phase of the Gene? (fwd)

Mike Miller mbmiller at SIRRONALD.WUSTL.EDU
Sun Apr 7 19:47:23 EST 1996


As suggested by Nick Tinker (below), my use of "Chrom1" and "Chrom2" 
could be confusing--they are maternal and paternal copies of the same 
chromosome.   Mike

---------- Forwarded message ----------
Date: Sun, 07 Apr 96 18:33:44 -0400
From: tinker at qtl.agrenv.mcgill.ca
To: mbmiller at SIRRONALD.WUSTL.EDU
Subject: Re: Phase of the Gene?

Mike,

I can't seem to post to this newsgroup, but you might consider clarifying
this explanation by replacing the words "Chrom1" and "Chrom2"
with "Homolog1" and "Homolog2" - i.e. they are both the same
chromosome, right?

Regards,
Nick Tinker.

>            Chrom1       Chrom2
>            ======       ======
>Alleles:      A,B          a,b     (coupling, or trans)
>Alleles:      A,b          a,B     (repulsion, or cis)
>
>Both the coupling phase and the repulsion phase will give the double
>heterozygote genotype, so we can't tell which is correct.  One chromosome
>is inherited from each parent, but we can't tell what the parental
>contributions were, unless we have more information. 
>
>That's a quick overview.
>
>Mike
>
>Michael B. Miller, M.S., Ph.D.
>Department of Psychiatry (Box 8134)
>Washington University School of Medicine
>4940 Children's Place,  St. Louis, MO 63110
>office phone: (314) 362-9428    FAX: (314) 362-9420
>WWW Homepage: ftp://sirronald.wustl.edu/pub/mbmiller/mike.htm
>




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