meaning of linkage disequilibrium

Bernie Charlton bernie at spine.med.utoronto.ca
Tue Feb 13 23:23:14 EST 1996


Could someone point me in the right direction in terms of references
for the following problem? (or if you're feeling _really_ generous,
tell me the answer yourself)

How do I relate linkage disequilibrium delta values to theta/rf - 
say marker A has a delta of .95 to my disease locus, while marker B
has a delta of .78. How can I use this to fine tune a map, and what
sort of pitfalls should I be wary of? Yes, this is related to homework,
but all the books on linkage that I've found in the library seem
to be overly concerned with software packages I don't have.

thanks,
bernie




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