Linkage analysis in large pedigrees

Claus S. Jensen claus at iesd.auc.dk
Fri Jul 5 00:52:16 EST 1996


I hereby announce the availability of the first alpha version (0.1) of
'block', a program for performing pedigree and linkage analysis in
large and complex pedigrees.
 
The program 'block' implements a method called blocking Gibbs
sampling.  The method is based on the Markov chain Monte Carlo method,
Gibbs sampling, but combines this stochastic method with exact local
computations to get a method that can successfully handle very large
and complex (e.g., inbred) pedigrees (thousands of individuals) with
an arbitrary number of alleles.  The method allows the user to test
the presence of linkage between two genes.      

As this is the first public version of the program, there is bound to
be errors and other kinds of problems.  All these should of course be
reported to me.

For more information, contact me, or download the program from :
 
  ftp.iesd.auc.dk/pub/packages/block/
 
The program is available for the architectures : Linux ELF and a.out,
Sparc Solaris and SunOS, FreeBSD, IRIX 64, and MS-DOS.

There is also a hopepage associated with the program at

  http://www.iesd.auc.dk/~claus/block.html


Greetings,
 
Claus Skaanning Jensen

-- 
    Claus Skaanning Jensen, Ph.D.-student at Aalborg University, Denmark
           claus at iesd.auc.dk, http://www.iesd.auc.dk/~claus




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