Linkage disequilibrium & Haplotypes
dcurtis at hgmp.mrc.ac.uk
Fri Mar 29 00:29:06 EST 1996
dmachugh at mail.tcd.ie (David MacHugh) wrote:
>We have haplotypic data from a number of microsatellites typed in human
>males on the X-chromosome.
>Basically we would like to determine the extent of linkage disequilibrium
>among these markers (STRs) using the GENEPOP program.
>Does anyone know of any theoretical objections to recoding the data as
>pseudo-homozygotes and testing for LD?
This sounds to me like it must tbe wrong - you're treating each
observation as if it were two observations.
>Perhaps someone might know a more appropriate method for dealing with this
>type of data.
I could think about it. Are you talking about examining each pair of
loci separately, or a group together?
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