heritability of schizophrenia

Mike Miller mbmiller at SIRRONALD.WUSTL.EDU
Thu May 16 15:56:56 EST 1996

On Fri, 17 May 1996, Irina Razin wrote:
> What is known and where I can read about heritability of
> schizophrenia? 

Read "Schizophrenia Genesis" by Irving I. Gottesman (1991), Freeman Press.

> Like, if it happened in both father's and mother's family (but not to
> them directly), what would be the chances for children and grandchildren?

This is not an easy question.  In fact, you should not trust an answer
based only on the information you've given.  Any answer would have to be
based on the exact pedigree structure AND on some model of transmission. 
We don't know how it's transmitted, so we can't produce a very reliable
answer.  But you'll get some really excellent ideas from Gottesman's book. 

Best wishes,


Michael B. Miller, M.S., Ph.D.
Department of Psychiatry (Box 8134)
Washington University School of Medicine
4940 Children's Place,  St. Louis, MO 63110
office phone: (314) 362-9428    FAX: (314) 362-9420
WWW Homepage: ftp://sirronald.wustl.edu/pub/mbmiller/mike.htm

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