heritability of schizophrenia

Mr. P.F. Linehan plinehan at hgmp.mrc.ac.uk
Mon May 20 04:20:41 EST 1996


.In article <Pine.SUN.3.93.960518214648.2731Z-100000 at sirronald> mbmiller at SIRRONALD.WUSTL.EDU (Mike Miller) writes:
.>Rcjohnsen has some good advice, but be careful!  It is easy to
.>misunderstand the entries in OMIM (Online Mendelian Inheritance in Man). 
.>Absolutely NONE of the linkage findings are really confirmed.  At this
.>time we still have not identified any gene that affects susceptibility to
.>schizophrenia.  Genetic markers are not useful in risk assessment for
.>schizophrenia.

Such a blanket assertion is IMHO misleading. They are starting to give 
consistent results. What is needed is larger studies, denser maps and
more genetically homogeneous populations. They are possibly not 
of immediate use, but will undoubtedly become so in the near future.

.>
.>Mike
.>
.>Michael B. Miller, M.S., Ph.D., M.P.E.
.>Department of Psychiatry (Box 8134)
.>Washington University School of Medicine
.>4940 Children's Place,  St. Louis, MO 63110
.>office phone: (314) 362-9428    FAX: (314) 362-942

Paul...





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