heritability of schizophrenia

Dave Curtis dcurtis at hgmp.mrc.ac.uk
Wed May 22 01:06:52 EST 1996


plinehan at hgmp.mrc.ac.uk (Mr. P.F. Linehan) wrote:

>.>Absolutely NONE of the linkage findings are really confirmed.  At this
>.>time we still have not identified any gene that affects susceptibility to
>.>schizophrenia.  Genetic markers are not useful in risk assessment for
>.>schizophrenia.

>Such a blanket assertion is IMHO misleading. They are starting to give 
>consistent results. What is needed is larger studies, denser maps and
>more genetically homogeneous populations. They are possibly not 
>of immediate use, but will undoubtedly become so in the near future.

I agree with Mike here. Genetic risk markers are not useful in risk
assessment for schizophrenia. Maybe they will be in future, who knows?
But they aren't now. I don't regard that as a "blanket assertion" but
a simple statement of fact.


Dave Curtis
http://www.gene.ucl.ac.uk/~dcurtis




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