heritability of schizophrenia

Mike Miller mbmiller at SIRRONALD.WUSTL.EDU
Wed May 22 08:29:13 EST 1996


On 20 May 1996, Mr. P.F. Linehan wrote:

> .In article <Pine.SUN.3.93.960518214648.2731Z-100000 at sirronald> mbmiller at SIRRONALD.WUSTL.EDU (Mike Miller) writes:
> .>Rcjohnsen has some good advice, but be careful!  It is easy to
> .>misunderstand the entries in OMIM (Online Mendelian Inheritance in Man). 
> .>Absolutely NONE of the linkage findings are really confirmed.  At this
> .>time we still have not identified any gene that affects susceptibility to
> .>schizophrenia.  Genetic markers are not useful in risk assessment for
> .>schizophrenia.
> 
> Such a blanket assertion is IMHO misleading. They are starting to give 
> consistent results. What is needed is larger studies, denser maps and
> more genetically homogeneous populations. They are possibly not 
> of immediate use, but will undoubtedly become so in the near future.

Everyone wants to conduct larger studies with denser maps, but it is
expensive.  Whether genetic markers will become useful in risk assessment
in the near future is a question that will be answered in the near future.
We don't know yet what will happen.




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