Introductory course in linkage analysis, London

Dave Curtis dcurtis at
Mon Jul 14 16:19:04 EST 1997

Course announcement:

St Bartholomew's Hospital, London
September 11-12, 1997

The course provides participants with an introduction to the
theoretical basis of genetic linkage analysis and the opportunity to
work through the analysis of example data sets, gaining experience of
the standard programs used to carry out linkage analysis and methods
of enhancing the efficiency and robustness of data management. It is
suitable for doctors and molecular biologists wishing to gain a basic
understanding of these topics.

Course trainers
Dave Curtis is a consultant and honorary senior lecturer in the
Department of Psychological Medicine at St Bartholomew's and Royal
London School of Medicine and Dentistry. Pak Sham is a senior lecturer
in the Departments of Biostatistics and Computing and Psychological
Medicine at the Institute of Psychiatry. Together and separately they
have considerable experience of supervising the analysis of many
different diseases, and they have developed a variety of innovative
methods of analysis, including the programs ERPA, CLUMP, ETDT and

The course will take place in the computer teaching laboratory of the
Robin Brook Centre in St  Bartholomew's Hospital, in the heart of the
City of London. Numbers will be strictly limited to 16 participants,
ensuring that no more than two people will share each PC. Course notes
are provided as hard copy and can also be browsed on screen, and
exercises can be demonstrated using a screen projector. 

The practical exercises cover the following topics: Carrying out
two-point analysis using MLINK; use of LINKAGE utility programs; use
of TABLE, QDB and DOLINK to manage data and analyses; performing
multipoint analysis with LINKMAP and VITESSE; lod score analysis of a
non-Mendelian disease and use of liability classes.

Theoretical seminars cover the following topics: Overview of
approaches to gene-mapping; biological basis of linkage and
explanation of associated statistics; two-point and multipoint
analysis; use of parametric and non-parametric methods for analysis of
non-Mendelian disorders; methods based on detection of association and
linkage disequilibrium.

Course fee of £240, including tuition, notes and lunch, is payable to
Queen Mary & Westfield College (Psychiatry) and should be sent to Ann
Tyrrell, Academic Dept Psychological Medicine, Alexandra Wing, Turner
Street, E1 2AD - Tel. 0171 377 7344. Please also include a brief note
about your previous experience and current interests. Requests for
further information can be made to dcurtis at or
p.sham at

Dave Curtis                     Tel   : +44-171-377-7729
Dept Adult Psychiatry           Fax   : +44-171-377-7316
3rd Floor Outpatient Building   Email : dcurtis at
Royal London Hospital           WWW   :
Whitechapel, London E1 1BB, UK

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