consanguinity loops and LINKAGE

E. Wijsman wijsman at
Sat Apr 25 17:57:13 EST 1998

Big pedigrees with lots of missing data and lots of loops take forever to
compute, no matter what linkage analysis program you use.  This is an
inescapable fact.  There is no perfect solution.

Research Professor			Ellen M. Wijsman
Div. of Medical Genetics and 		1914 N 34th St., suite 209
Dept. Biostatistics			Seattle, WA   98103
BOX 357720, University of Washington	(Note:  Use this address
Seattle, WA   98195-7720	 	 EXACTLY as given above, and
phone:  (206) 543-8987			 use ONLY for express mail!!!)
fax:    (206) 616-1973			email:  wijsman at

On 21 Apr 1998, Sabine Faure wrote:

> Hallo,
> I try to analyse data on an inbred family. But using LINKAGE, it takes weeks...
> when it succeeds!
> The family is composed of 71 individuals out of which only 32 DNA are available
> (8 affected individuals). And there are 7 consanguinity loops.
> I know I could perform homozigosity mapping, but at the moment I'd like to
> obtain LOD scores for some markers.
> Do you have any idea for me?
> Thanks in advance,
> Sabine.

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