consanguinity loops and LINKAGE

E. Wijsman wijsman at u.washington.edu
Sat Apr 25 17:57:13 EST 1998


Big pedigrees with lots of missing data and lots of loops take forever to
compute, no matter what linkage analysis program you use.  This is an
inescapable fact.  There is no perfect solution.

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On 21 Apr 1998, Sabine Faure wrote:

> 
> Hallo,
> 
> I try to analyse data on an inbred family. But using LINKAGE, it takes weeks...
> when it succeeds!
> The family is composed of 71 individuals out of which only 32 DNA are available
> (8 affected individuals). And there are 7 consanguinity loops.
> I know I could perform homozigosity mapping, but at the moment I'd like to
> obtain LOD scores for some markers.
> Do you have any idea for me?
> Thanks in advance,
> 
> Sabine.
> 
> 
> 




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