Future change in genetic linkage analysis?

Y.F.LEUNG yfleung at cuhk.edu.hk
Sat Dec 9 03:53:47 EST 2000


I came up with a question when I realized the real physical distance
sometimes differs a lot with the estimated physcial distance from
genetic distance (with the traditional rule of thumb: 1cM roughly equals
to 1Mbps) in my linkage analysis.When the human genome project is
finished, the exact physical position of all microsatellite markers and
SNPs are known.  I wondered if we can incorporate the real physical
distance in the traditional genetic linkage analysis (depends on
recombination fractions or genetic distances) to facilitate a faster and
more accurate disease trait loci mapping.

Department of Ophthalmology and Visual Sciences
Chinese University of Hong Kong
3/F Hong Kong Eye Hospital
147K Argyle Street, Hong Kong
Tel: (852) 27623152 Fax: (852) 27159490
email: leungyukfai at hotmail.com, yfleung at cuhk.edu.hk

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