NEW ON THE EXP MED JOB LISTING (POST DOC IN FRANCE: PRIONS and

[Graham Dellaire]

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NEW ON EXP MED JOB LISTINGS


Post-doc in France:

ROLE OF THE PRION PROTEIN IN TRANSMISSIBLE SPONGIFORM
ENCEPHALOPATHIES

ROLE DE LA PROTEINE DU PRION DANS LES ENCEPHALOPATHIES SPONGIFORMES
TRANSMISSIBLES=20

=20
Sylvain Lehmann=20

Washington University School of Medicine,=20

St Louis, MO, USA=20

Project description:=20

- Specific subject: Normal and Pathogenic function of the prion protein=
=20

Research areas for the fellowship may be:

1- Role of the prion protein in cell adhesion and at the synapse.
Several transfected cell lines expressing wild-type and mutated
prion proteins will be available to start this project.=20

2- Processing of the prion protein (cleavage, degradation=85) in cell
culture and in tissues. Development of immunological tools
to detect prion protein fragments.=20

3- Creation of new cell culture models of infectious forms of
transmissible spongiform encephalopathies=20

In France, post doctoral fellowships have to be jointly applied by the
candidate and the laboratory. Therefore, this offer aims,
in the first place, to write an application for a post doctoral
fellowship. I have just spend 4 years in the States (see below) and
I will start my own group in Montpellier (France) to work on prion
diseases. If you are interested, we can apply together for a
fellowship.=20


- Theme propose: Etude de la fonction normale et pathologique de la
proteine du Prion. Les differents domaines de recherche
sur lesquels la demande peut etre faite sont:

1- L'Etude du role physiologique de la proteine du prion, en particulie=
r
dans les mecanismes d'adhesion et de reconaissance
intercellulaire et au niveau synaptique. Differentes lignees cellulaire
qui expriment des proteines du prion sauvage et mutees
sont disponibles pour debuter ce projet.=20

2- Etude du clivage proteolytique de la proteine du prion et plus
generalement de son metabolisme. Etudes qui pourront etre
realisees en culture cellulaire mais egalement a partir de tissus. Mise
au point de techniques immunologiques de detection des
differents fragments de la proteine du prion.=20

3- Mise au point de nouveaux modeles en culture cellulaire des formes
infectieuses des encephalopathies spongiformes
transmissibles=20

En France, il est necessaire d'avoir un candidat et un laboratoire pour
postuler a une bourse post-doctorale. Cette proposition
a pour but, en premier lieu, d'etablir un dossier de demande de bourse
pour rejoindre mon laboratoire. Je viens de passer 4
ans aux USA a travailler sur la proteine du prion (voir ci-dessous) et
je vais m'installer a Montpellier a la rentree 1997. Si vous
etes interesse(e), nous pouvons postuler ensemble a une bourse


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| Graham Dellaire                   =20
|				  =20
| Division of Experimental Medicine =20
| Dept of Medicine, McGill University
|(http://www.medcor.mcgill.ca/EXPMED/DOCS/expmed.html)                 =
   =20
           =20
|=20
| e-mail: dellaire at odyssee.net       =20
| Fax: (514) 896 4689              =20
| Vox: (514) 281 6000 ext. 6936
|=20
| Bionet: bionet.molbio.recombination
|         bionet.genome.gene-structure                 =20
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| Snail Mail:                        =20
| Institut du Cancer de Montreal  =20
| Centre de Recherch L.C. Simard    =20
| 1560 Sherbrooke St. East        =20
| Montreal, Quebec, CANADA          =20
| H2L 4M1                              =20
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