Post Doc (beta globin LCR and TAL 1)

Emery H. Bresnick ehbresni at
Wed Mar 26 09:31:57 EST 1997

                   March 25, 1997
         A Postdoctoral Research Associate position is currently available
 in my laboratory to participate in NIH-funded studies on mechanisms of
 locus control region function and regulation of hematopoiesis.  Questions
 being investigated include - how is the human beta-globin lcr shared by
 multiple promoters on a chromosome, what are the requirements for
 long-range gene activation by lcrs, and do the protein components of the
 lcr form ordered nucleoprotein complexes?
         A second project focuses on the biology and regulation of certain
 hematopoietic regulatory proteins.  One focus is on the TAL1 protein, an
 erythroid-specific transcription factor and crucial regulator of mammalian
 development.  The regulatory regions of the TAL1 gene are disrupted by a
 chromosomal deletion in patients with acute T-cell lymphocytic leukemia. 
 This deletion results in ectopic expression of TAL1 in T-cells, and thus
 may be directly involved in leukemogenesis.  One aim is to delineate the
 cis-acting elements and trans-acting factors which drive TAL1
 in erythroid and T-cells.  A second aim focuses on identifying target
 for TAL1.
         Potential applicants should submit a brief description of research
 interests, a curriculum vitae, and the names of three individuals for
 recommendations to:
 Emery H. Bresnick, Ph.D.
 University of Wisconsin-Madison
 Department of Pharmacology
 387 Medical Science
 1300 University Avenue
 Madison, WI 53706
 TEL. (608) 265-6446
 E-Mail - ehbresni at

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