about introns

Elisa Steinberg esteinbe at midway.uchicago.edu
Mon May 11 14:49:04 EST 1998


Alvaro:
	There are genes that have non-coding 5'-UTRs, like the myc gene.  The
first exon of myc is noncoding, and the first translated ATG is in the
second exon.  Therefore, myc has an intron in the 5'UTR.  Introns in the
3'UTR are more rare, apparently because of the pathway of degradation of
mRNAs with premature stop codons.  This pathway seems to recognize as
premature stop codons, any in frame stop codon that occurs before the
last intron.  mRNAs that have premature codons by this definition, are
degraded by this pathway that is widespread in eukaryotes, from yeast to
man.  Nevertheless, there are spliced RNAs that do not encode a protein,
like the Xist RNA that is involved in regulation of X inactivation in
mammals (see review in Cell 93:305-308, 1998)> about introns
> 


> alvaro mailhos (alvaro at genetica.edu.uy)
> Fri, 08 May 1998 19:45:14 -0300
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