Multinucleated phenotypes.. causes?

[G. Dellaire, Ph.D]

I have a cell line with a peculiar
multinucleated/micronucleated phenotype.  Does anyone
know of some of the mutant proteins or disrupted
pathways that may be involved in producing such a
phenotype?  So far, most of the literature I have
found points to disruption of microtubules and
proteins involved in regulating the contractile ring
function during cytokinesis. If you have read or know
of any other causes please post here or to my e-mail.
 
Cheers,

Graham Dellaire
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Graham Dellaire, Ph.D.
 
 MRC Human Genetics Unit
 Western General Hospital
 Crewe Road
 Edinburgh, UK
 EH4 2XU
 
 Fax: +44 (0)131 343 2620
 Phone: +44 (0)131 332 2471
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Moderated
bionet.genome.gene-structure


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