Postdoctoral Position: Chromatin and
G.Dellaire at somewhere.ac.uk
G.Dellaire at somewhere.ac.uk
Sun Apr 16 06:59:33 EST 2000
From: "Jerry L. Workman, Ph.D." <jlw10 at psu.edu>
Reply-to: jlw10 at psu.edu
Organisation: HHMI / Penn State
Postdoctoral Positions in Chromatin Remodeling and
Howard Hughes Medical Institute Research
Laboratories, Penn State
We are seeking talented scientist that have a keen
interest in studying
the relationship between chromatin structure and
Experience in protein biochemistry, molecular
biology, yeast genetics
and/or mammalian cell culture is a plus. Our
laboratory is currently
emphasizing the identification and analysis of
remodeling activities (e.g. SWI/SNF) and native
adaptor/histone acetyltransferase complexes (e.g.
SAGA). The functions
of such complexes provide exciting new concepts in
gene regulation. We
are looking for colleagues who will share our
enthusiasm for these
studies and will fully participate in the growing
chromatin/transcription research community (7
laboratories) at Penn.
I have listed below a few recent manuscripts from
our laboratory that
can provide examples of our approaches to these
questions. A more
detailed description of our research interest can be
found at our
Grant, P.A., Duggan, L., Côté, J., Roberts, S.M.,
Candau, R., Ohba, R., Owen-Hughes, T., Allis,
C.D., Winston, F.,
Berger, S.L. and Workman, J.L. (1997). Yeast Gcn5
functions in two
multisubunit complexes to acetylate nucleosomal
characterization of an ADA complex and the SAGA
(Spt/Ada) complex. Genes
Dev. 11, 1640-1650..
Côté, J., Peterson, C.L. and Workman, J.L. (1998).
nucleosome structure by the SWI/SNF complex persists
detachment, enhancing subsequent transcription
factor binding. Proc.
Natl. Acad. Sci. USA 9, 4947-4952.
Utley, R.T., Ikeda, K., Grant, P.A., Côté, J.,
Steger, D. J.,
Eberharter, A., John, S. and Workman, J.L. (1998).
activators target histone acetyltransferase
complexes to nucleosomes.
Nature 394, 498-502.
Grant, P. A., Schieltz, D., Pray-Grant, M. G.,
Steger, D. J., Reese, J.
C., Yates III, J. R., Workman, J. L. (1998). A
subset of TBP-associated
factors, TAFIIs, are integral components of the SAGA
complex that are
required for nucleosome acetylation and
transcription stimulation. Cell
Neely, K.E., Hassan, A.H., Wallberg, A.E., Steger,
D.J., Cairns, B. R.,
Wright, A.P.H., and Workman, J.L. (1999).
targeting of the SWI/SNF complex to promoters
from nucleosome arrays. Mol Cell. 4, 649-655.
John, S., Howe, L., Travov, S.T., Grant, P.A.,
Sternglanz, R., and
Workman, J.L. (2000) The Something about silencing
protein, SAS3, is the
catalytic subunit of the NuA3 complex, a
TAF30-containing HAT complex
that interacts with the Spt16 subunit of the yeast
complex. Genes Dev. In press.
Vignali, M., Steger, D.J., and Workman, J.L. (2000)
acetylated histones resulting from GAL4-VP16
targeting of the SAGA and
NuA4 complexes to nuclesome arrays. EMBO J. in
To apply send letter, cv and names of three
Jerry L. Workman, Ph.D.
HHMI / Penn State
306 Paul M. Althouse Laboratory
University Park, PA 16802
Phone: (814) 863-8256 Fax: (814) 863-0099 E-mail:
JLW10 at psu.edu
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