The large scale mutagenesis project
janczek at aol.com
Tue Mar 21 17:50:12 EST 2000
The Jackson Laboratory launches large-scale
The Jackson Laboratory (TJL) has recently launched a
collect a large number of mouse mutants to provide new
the study of human neurological diseases. TJLâs
Facility will generate, identify and characterize new
mutants in a
range areas including motor function, epilepsy,
hearing, vision, learning, ingestive behaviors,
sensorimotor gating, substance abuse and anxiety.
As part of this program, supervisor Dr. Kevin Seburn,
Instruments in February, 1999 to develop an automated
use in the initial detection of deviant mice. The
result of this
collaboration was a state-of-the-art live-in cage
(dubbed âCCMSâ or
Comprehensive Cage Monitoring System) that allows
non-invasive collection of several physiological and
simultaneously (activity, food and water consumption,
performance). The proposal for the development of
these cages as an
automated screening tool was based on the simple
premise that the
of aberrations in any complex system is best achieved
examining several parameters. To test this notion a
variety of known
subtle, non-visible mutant mice were placed in the
data were then compared to controls using a specially
algorithm that exploited the multiple measures
provided by CCMS.
results were very positive and showed that at least
six different types
mutants were successfully detected using CCMS data.
The use of CCMS as
tool for initial mutant detection in combination with
screens promises to be an efficient means of
mouse models for study of neurological disease.
The Jackson Laboratory, founded in 1929, is a world
leader in mammalian
genetics research. With approximately 1,000 employees,
independent facility has a mission to improve the
quality of human life
through discoveries arising from its own genetic
research and by
the research and education of others. Further
information on The
Laboratory can be obtained at http://www.jax.org.
Information on Columbus Instruments equipment used in
this project is
available at: http://www.colinst.com
Jan Czekajewski, Ph.D.
janczek at aol.com
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