Postdoctoral Position: Epigenetic(Trans)Gene

Heriberto Cerutti hcerutti1 at
Mon Sep 11 17:51:52 EST 2000

Postdoctoral Position:  Epigenetic (Trans)Gene

An NSF-funded Postdoctoral position is available
immediately to study
the molecular mechanisms responsible for epigenetic
silencing.  In plants, transgenes are silenced at both
and post-transcriptional levels.  Similar mechanisms
appear to control
the expression of transposable elements and might also
be involved in
the developmental regulation of gene expression.  The
project will
entail functional genomic approaches, such as
insertional mutagenesis, for the isolation of genes
involved in
epigenetic silencing, the molecular characterization
of the mutants, 
the identification of interacting proteins by affinity
sequencing.  Arabidopsis thaliana and the unicellular
green alga
Chlamydomonas reinhardtii are being used as model
systems.  We have
recently cloned a novel DEAH-box RNA helicase that is
required for
transgene and transposon silencing in Chlamydomonas
(Wu-Scharf et al.,
Science 290, in press [2000]).  The successful
candidate will have
access to state-of-the-art facilities in the George W.
Beadle Center 
Genetics Research and acquire experience in chromatin
proteomics, and functional genomics.  A background in
and biochemistry is desirable.  Applicants should send
a CV, statement
of research experience, and three letters of reference
to:  Dr.
Heriberto Cerutti, School of Biological Sciences,
University of
Nebraska-Lincoln, E211 Beadle Center, P.O. Box 880666,
Lincoln, NE
68588-0666; phone (402) 472-0247; fax (402) 472-8722;
hcerutti1 at  Review of applications will begin
October 1, 2000,
and will continue until a suitable candidate is found.
 UNL is 
to a pluralistic campus community through Affirmative
Action and Equal
Opportunity and assures reasonable accommodation under
the Americans
With Disabilities Act.



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