r.jefferis at bham.ac.uk
Mon Dec 5 11:15:08 EST 1994
My interest is glycosylation of secreted antibody molecules and its
influence on effector functions.However,I want to be able to quote studies in which it has been shown that glycosylation is
in which it has been shown that glycosylation is essential to the function
of receptor molecules; any receptor not just antibodies.
Also, I frequently assert that IgG antibodies are unique (so far !) in
having an oligosaccaride moiety which is essentially "sequestered" within
the quaternary structure of the molecule,the CH2 domains of the Fc region.
Would anyone like to contest this assertion ? Please give details with
publications, if possible.
Kind regards, ROY
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