On 10 Apr 1995, Bob Lauder wrote:
> In article <3lrio2$ig6 at news.duke.edu>, srps at galactose.mc.duke.edu (Steven Pirie-Shepherd) says:
> >
> >I need to know the structure of the tetrasaccharide sialyl Lewis ^x. I
>> NeuAc(alpha2-3)Gal(beta1-4)GlcNAc(alpha1-3)Fucose.
>> I think.
>> ================================================================
> Bob Lauder R.Lauder at lancaster.ac.uk> Division of Biological Sciences Tel +(44)(0)1524 65201
> Lancaster University, Lancaster, UK Fax +(44)(0)1524 843854
>>WRONG!!
The structure of sialyl Lewis x is:
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)GlcCer
This is for the simplest glycosphingolipid carrying the antigen. The
outermost galactose and the fucose are both attached to the GlcNAc
residue, at the 4 and 3 positions respectively. Nomenclature is based on
the IUPAC-IUB commision (published in JBC vol. 262, pp. 13-18, 1987).
A good general reference for structures carried on glycosphingolipids is
"Glycosphingolipids: Structure, Biological Source, and Properties" by
Stults, et al. in Methods of Enzymology Vol. 179, pp.167-214. Under the
"comment" column of these extensive structural tables, trivial and blood
group antigen nomenclatures are listed.
BOB: Please be careful about putting incorrect structures on the net!
