Sialyl Lewis!?

RONALD L SCHNAAR rschnaar at WELCHLINK.WELCH.JHU.EDU
Mon Apr 10 07:32:55 EST 1995



On 10 Apr 1995, Bob Lauder wrote:

> In article <3lrio2$ig6 at news.duke.edu>, srps at galactose.mc.duke.edu (Steven Pirie-Shepherd) says:
> >
> >I need to know the structure of the tetrasaccharide sialyl Lewis ^x. I 
> 
>  NeuAc(alpha2-3)Gal(beta1-4)GlcNAc(alpha1-3)Fucose.
> 
> I think.
> 
> ================================================================
> Bob Lauder				R.Lauder at lancaster.ac.uk
> Division of Biological Sciences		Tel +(44)(0)1524 65201
> Lancaster University, Lancaster, UK	Fax +(44)(0)1524 843854
> 
> 
WRONG!!

The structure of sialyl Lewis x is:

NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)GlcCer

This is for the simplest glycosphingolipid carrying the antigen.  The 
outermost galactose and the fucose are both attached to the GlcNAc 
residue, at the 4 and 3 positions respectively.  Nomenclature is based on 
the IUPAC-IUB commision (published in JBC vol. 262, pp. 13-18, 1987).

A good general reference for structures carried on glycosphingolipids is 
"Glycosphingolipids:  Structure, Biological Source, and Properties" by 
Stults, et al. in Methods of Enzymology Vol. 179, pp.167-214.  Under the 
"comment" column of these extensive structural tables, trivial and blood 
group antigen nomenclatures are listed.

BOB:  Please be careful about putting incorrect structures on the net! 




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