Sources of A23187 and thapsigargin

Iain Wilson wilson at edv1.boku.ac.at
Sat Apr 15 06:21:52 EST 1995


treefrog at u.washington.edu (Bryce Chackerian) wrote:
>
> A recent report indicated that the drugs A23187 and thapsigargin inhibit 
> O-linked glycosylation.  Does anyone out there know who makes these drugs 
> and if you can purchase them.  Apparently a company called L.C. Labs in 
> Woburn, Mass manufactures thapsigargin; has anyone heard of them and/or 
> send me their phone number?
> 
> Thanks in advance
> Bryce Chackerian 
> Dept. of Microbiology
> U of Washington

A quick look at the 1995 Sigma catalogue shows that thapsigargin
(potent cell permeable IP3-independent intracellular calcium
releaser and inhibitor of microsomal Ca-ATPase) is listed. Price
127.10 Deutschmarks for 500 micrograms. Also, under calcium 
ionophore A23187 is listed a number of forms of either free acid
or salts - starting from around 32 DM per mg. (For some reason
even though Sigma have a 'Austrian' catalogue, the prices are in DM!)
As for L.C. Labs, never heard of them!

Iain

---------------------------------------------------------------
Iain Wilson                        Institut für Chemie           
Tel: 43-1-47654-6065               Universität für Bodenkultur   
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E-mail: wilson at edv1.boku.ac.at     A-1180, WIEN, Austria

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