evolution of glycoprotein glycosylation

Martin Dalziel martin at axford.demon.co.uk
Tue Dec 19 08:11:41 EST 1995


Dear Neil,

This may or may not be of interest to you but are you aware of the 
occurence of bacterial capsular polysaccharide polysialylation?
Usually attached to membrane proteins (in particular a 20 kDa protein) 
found in E coli K1 (poly-sialyl a2,6 linked, both 7 and 9 0 acetyl), E 
coli K92 (Alternating a2,8 and a2,9 linked poly-sialyl), Neisseria 
meningitidis group B and  Neisseria meningitidis group C ( both 
polysialyl a2,8), Pasteurella haemolytica A2 (polysialyl a2,8) and 
Moraxella nonliquefaciens (polysialy a2,8). see Glycobiology 2(1), pp 5 
- 23 1992.
These are human pathogenic strains and not those used for E.coli
recombinant work however.

There are almost certainly other more interesting types to be found, 
such as those mentioned by Iain.

martin
martin at axford.demon.co.uk 





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