> Does anybody know of examples whose subcellular distribution may be
> etermined by their differential glycosylation state. This has been
> suggested as a possible reason as to why a particular protein may exist
> in both a membrane-bound and secreted form, both exhibiting different
> glycosylation patterns.
>> Kieran Breen
> Dept. of Pharmacology, University of Dundee
>k.c.breeb at dundee.ac.uk
>>I'm assuming you mean plasma membrane rather than an intracellular membrane
>>localisation? The only instance I am aware of where glycosylation is
>>responsible
>>for _determining_ subcellular distribution is in the case of lysosomal
>>targeting by
>>Man-6-P.
>>David Ashford
>>Plant Glycoprotein Research Facility
>>Dept of Biology, University of York
>>da5 at york.ac.uk
O-GlcNAc is another type of glycosylation that determines the subcellular
distribution (from Gary Hart's group) (Hart et al., Ann.Rev.Biochem. 1988 Vol
58, pp 841). Unfortunately I do not have any recent reference.
Balaji
balaji at helix.nih.gov
