Degradation pathway through high mannose glycosylation?
WILSON at edv1.boku.ac.at
Fri Mar 31 03:25:58 EST 1995
> Date: 30 Mar 95 20:41:54 GMT
> From: ching at tgevax.life.uiuc.edu (Ching Yuan)
> Reply-to: ching at tgevax.life.uiuc.edu (Ching Yuan)
> To: "bionet.glycosci mail newsgroup" <bionet-news at dl.ac.uk>
> Subject: Degradation pathway through high mannose glycosylation?
> Hi! Netter
> We recently sequenced some glycoprotein's N-oligosaccharide.
> (With exoglycosidases)
> To our surprise, this oligosaccharide has a high-mannose type abridged
> structure instead of hybrid, abridged type found in other species.
This may not be a surprise since there is species-specific and
cell-specific glycosylation for the same protein is well known.
> Since in other species(for the same protein), this kind of oligosaccharide
> mediates the sorting and degradation pathway of this protein, we've
> experienced some difficulties to explain this data.
What sort of degradation pathway are you refering to -
endocytosis/lysosomal? 'Mannose' receptors occur on macrophages (for
instance) and are involved in uptake to the lysosomes. Suggested
reading would be: Kurt Drickamer's article in the book 'Molecular
Glycobiology' ed. Fukuda and Hindsgaul (IRL Press, 1994).
> Can anyone tell me any oligosaccharide-mediated degradation pathway
> involving high-mannose structure beside hybrid or complex
> Also, can anyone give us the information about a biotech company
> called Oxford?
I presume you refer to Oxford GlycoSystems? The US telephone number
is given as 718-712-2693.
Iain Wilson Institut fuer Chemie
Tel: 43-1-47654-6065 Universitaet fuer Bodenkultur
Fax: 43-1-310-5176 Gregor-Mendel-Strasse 33
E-mail: wilson at edv1.boku.ac.at A-1180, WIEN, Austria
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