Molecular biologist, research fellowship: Genetic Immunization project

Jan Hansen janhan at dna
Thu Aug 22 08:45:50 EST 1996


Skillful and creative molecular biologist  (biochemist, biologist,
veterinary or medical) is needed as soon as possible for a position at
the Laboratory of Molecular Virology, Department of Virology, Statens
Serum Institute, DK2300 Copenhagen S, Denmark.

The Department of Virology is the Danish Central Laboratory for the
Diagnosis of Viral infections in Humans. The department is one of seven
global WHO Collaborating Centers for Virus Reference and Research and
does research in viral genetics, biology and diagnostics. The
department consists of 6 laboratories with 70 employees of whom 11 are
graduated. The Molecular Virology Laboratory is engaged in DNA vaccine
research and development of PCR diagnostic assays.  Besides research
and diagnostic service - that in 1995 included 160.000 investigations
involving more than 70 different assay analyses - control of virus
inactivation procedures on plasma products for national and
international companies is performed. Further, the department is
responsible for the reference - and control function for national
laboratories on HIV-diagnostics, and the department participates in the
education of clinical microbiologists, Ph.Ds. students, and M.Ds.

The Job: The project is development of genetic immunization technology
(DNA vaccine) using HIV antigens as the model system. It involves
cloning in various expression vectors of viral antigens and epitopes,
in vitro translation, construction of fusion proteins, transient/stable
expression,  and MHC class-I presentation. The immunological properties
of the various DNA vaccines will be evaluated in mouse strains
including HLA-transgenic mice by monitoring isotype specific antibodies
(TH1-TH2) and CTL chromium release assays using MCH matched cell lines

The project is a collaborative study between the Retrovirus laboratory,
Statens Serum Institute), Center for Biological Sequence Analysis,
Technical University Copenhagen, Institute for Medical Microbiology &
Immunology, Panuminstitut, Copenhagen and international collaborators.

The Molecular Virology laboratory is also developing gene based virus
diagnostic assays (quantitative PCR, RT/PCR, sequencing, and PNA/DNA
probing), which will involve some technical molecular biological
supervision..

Further Information Contact chief of Molecular Virology Laboratory
Anders Fomsgaard 
phone: +45 3268 3460, 
Fax: +45 3268 3148, 
E-mail: afomsgaard at vir.diag.ssi.dk

Application to Bent Faber Vestergaard, head of Department of Virology.
Deadline September 20, 1996.
Statens Serum Institute 5 Artillerivej, DK-2300 Copenhagen S, Denmark,
phone +45 3268 3268.



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