membrane-permeable neuraminidase inhibitor

[Derek Toomre]

Please...Could anyone tell me if they know of a membrane permeable
neuramidase inhibitor?

I know that potent 4-guanidino-Nue5Ac2en analogues exist, but are these or
other inhibitors able to penetrate the membrane barrier?

Specifically I would like to block the sialidase activity of influenza A
infected MDCK cells so that the HA which is sent out to the PM remains
sialylated?

Thanks for any help.

-Derek

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Dr. Derek Toomre
European Molecular Biology Laboratory (EMBL)
Meyerstrasse 1
69117 Heidelberg
Germany

(+49) (6221) 38 75 12 (telefax)
(+49)(6221) 38 73 11 (telephone)
email:  toomre at embl-heidelberg.de