unprotection of groups
Juan L. Navia
jlnavia at IX.NETCOM.COM
Tue May 27 20:34:01 EST 1997
kzhao at biovx1.biology.ucla.edu wrote:
> For Sunny's question of unprotection of glucuronide:
> Dissolve your compound in methanol (cold), flux ammonia for 1hr during stirring,
> and store in a refrigerator o/n. Acetate is recovered by filtration. See
> J. Histochem. Cytochem. 2: 209-229, 1954 for details on similar compound.
> Good luck,
> Ke-Wei Zhao, Ph.D.
> Dept. Biol. Chem.
> UCLA School of Medicine
> Los Angeles, CA 90095
Any chance of ending up with glucuronamide under the stated conditions?
Might KCN/MeOH do better? Mind you, careful of HCN vapors on work-up!
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