unprotection of groups

Juan L. Navia jlnavia at IX.NETCOM.COM
Tue May 27 20:34:01 EST 1997


kzhao at biovx1.biology.ucla.edu wrote:
> 
> For Sunny's question of unprotection of glucuronide:
> 
> Dissolve your compound in methanol (cold), flux ammonia for 1hr during stirring,
>  and store in a refrigerator o/n.  Acetate is recovered by filtration.  See
> J. Histochem. Cytochem. 2: 209-229, 1954 for details on similar compound.
> 
> Good luck,
> 
> Ke-Wei Zhao, Ph.D.
> Dept. Biol. Chem.
> UCLA School of Medicine
> Los Angeles, CA 90095
++++++++++++++++++++++++++++++++

Any chance of ending up with glucuronamide under the stated conditions?
Might KCN/MeOH do better?  Mind you, careful of HCN vapors on work-up!

Juan



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