O-glycan degradation

Teis Jensen t.jensen at immi.ku.dk
Tue Sep 2 04:24:04 EST 1997


Dear glycoscientists

I am an Immunologist and my interest is how glycoproteins are processed
into peptides and presented by MHC class II molecules to T cells. I am
especially interested in O-glycosylated proteins and I am interested in T
cells that can recognize antigenic peptides partly defined by small
O-glycans. 

However, I would like to know more about how O-glycans on proteins are
degraded when "used". Where is this actually going on ? Is it limited to a
single specialized compartment (eg. lysosome) or can it also happen in
other acidic compartments (eg endosomes) ? What enzymes are involved in
this process ? Is the enzyme responsible of removing O-GalNAc known in
humans (and mice) ?

If you have knownledge to articles or reviews please send it to my e-mail
address. Everything has my interest

sincerely

Teis


****************************************
Teis Jensen, M.Sc., Ph.D. student
INSTITUTE OF MEDICAL MICROBIOLOGY
AND IMMUNOLOGY
University of Copenhagen
Panum Building, 22.5.22
Blegdamsvej 3C
DK-2200 Copenhagen

Tlf: (+45)3532 7867
Fax: (+45)3532 7865
e.mail: t.jensen at immi.ku.dk

****************************************



More information about the Glycosci mailing list