clarification

Barry Shur barry at cellbio.emory.edu
Tue Jan 20 14:06:48 EST 1998


Please distribute:


CLARIFICATION: OPEN TO USA AND NON-USA CITIZENS/RESIDENTS


POSTDOCTORAL POSITIONS IN MAMMALIAN FERTILIZATION


NIH-funded postdoctoral positions are available immediately to study
the biochemistry of mammalian gamete recognition. Recent studies show
that sperm surface galactosyltransferase is a receptor for ZP3
oligosaccharides in the egg zona pellucida
(<fontfamily><param>Geneva</param>Nature, 1992,
357:589-593</fontfamily>). Aggregation of galactosyltransferase by
multivalent ZP3 oligosaccharides leads to activation of a
heterotrimeric G-protein cascade, which culminates in the acrosome
reaction (Science, 1995,<fontfamily><param>Geneva</param>
269:1718-1721</fontfamily>). Although galactosyltransferase-null sperm
do not bind ZP3 oligosaccharides nor undergo an acrosome reaction, they
still bind to the zona pellucida (Development,
1997,<fontfamily><param>Geneva</param> 124:4121-4131</fontfamily>).
This suggests that galactosyltransferase cooperates with other sperm
surface components to form a multimeric receptor complex. Postdoctoral
training will be in the biochemical and molecular analysis of sperm
surface and cytosolic proteins that cooperate with
galactosyltransferase to facilitate sperm-egg recognition and
intracellular signaling. 


Experience in biochemistry, molecular biology and/or mammalian gamete
biology are desirable.


Pleas send CV to:


Barry D. Shur, Ph.D.

Department of Cell Biology

Emory University School of Medicine

1648 Pierce Drive, Room 100

Atlanta, GA 30322 

USA

voice: 404-727-4315

fax: 404-727-6256

email: barry at cellbio.emory.edu









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