2,3-DGP

hillary gorman hillary at hillary.net
Mon May 25 09:45:28 EST 1998


On 25 May 1998 13:24:48 GMT,<rdt at NOSPAM.qucis.queensu.ca> wrote:
*It's been reported that chronic fatigue patients have abnormally
*low levels of the blood enzyme 2,2-diphosoglycerate.  Can anyone
*tell me what is the normal role of this enzyme and how it is
*normally made?  Please send e-mail (remove NOSPAM from the address).

2,3-DPG is a byproduct of glycolysis, and it normally functions to shift
the oxygen/hemoglobin dissociation curve to the right, promoting the
release of oxygen in the tissues, in dogs and humans, but not in cats or
cattle. I forget about the horse.

Ainmals or people with phosphofructokinase deficiency get a buildup of
DPG, this causes a decrease in O2 delivery, and increased Hb-O2 affinity.

hillary

-- 
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