Journal Watch: MHC and intracellular self

FORSDYKE at QUCDN.QueensU.CA FORSDYKE at QUCDN.QueensU.CA
Wed Aug 19 09:19:20 EST 1992


In article <1992Aug19.040540.21000 at news2.cis.umn.edu>, shiv at tsp.med.umn.edu
(Shiv Prasad) says:
>In article <92231.161618FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA>
>writes:
>>
>>   Yes. So, what determines the concentration of self proteins in a cell?
>>
>>  Yes. So what determines the concentration of viral proteins in a cell?
>
>Prasad: Synthesis - Turnover would give us the number of copies of protein X

  Forsdyke: Yes, synthesis and degradation (turnover).  OK. Now be patient and
            tell me what determines rates of synthesis and degradation.

>> Under what conditions would the virus be in "excess"?

  Prasad:
>Depends on the virus.

  Forsdyke: OK. Let's just take a "generic" virus which goes about its
            business within the cell and eventually lyses the cell.
            It will make some viral proteins more than others, but a minimum
            of one protein would be     necessary in order to get a foreign
            peptide displayed at the cell surface with MHC class I.

>  Prasad:           Goerge Chacko indicated earlier that homotypic adhesion
>was dependent on protein concentration, pH, and the notorious "other factors."
>Since we realy can't say for certain which proteins agggregate better at
>cellular pH, and how the "other factors" play a role, we seem to be left with
>[protein] as the only thing that we can grasp.
>
 Forsdyke: At this stage it should be noted that one of the "other factors",
           as implied in my original test-tube scenario , is the concentration
           of other proteins in the crowded cytosol. More of this later.
>
>>          Sincerely,
>>          Don Forsdyke
>>
>>References:   Forsdyke, D. (1992) Bionet.immunology 812 947edt
>>              Prasad, S. (1992) Bionet.immunology 814 1516gmt
>>              Forsdyke, D. (1992) Bionet.immunology 817 1757edt
>>              Prasad, S. (1992) Bionet.immunology 818 133gmt
>               Forsdyke, D. (1992) Bionet.immunology 818, 1616edt
                Prasad, S. (1992) Bionet.immunology 819, 405gmt



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